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Director / Senior Director, Toxicology

Reporting into the Chief Scientific Officer, the Director/Senior Director of Toxicology will be responsible for the management of the non-clinical toxicology function within Janux Therapeutics. The incumbent will focus on the design, execution and oversight of non-clinical safety studies to drive forward IND-enabling studies into the clinic. The ideal candidate will be a key contributor to the therapeutic development process, representing the toxicology function in meetings with executive management and regulatory authorities to include presentations of strategy, results, and progress-versus-goals. In addition, he/she will author regulatory submissions, negotiate technical aspects of contracts, and manage the toxicology-specific outsourcing plans and budgets.


  • Develop, execute and direct the toxicology strategy for each drug candidate throughout the stages of development; from preclinical to late-stage clinical trials.
  • Design, execute and direct all non-clinical studies, including exploratory and GLP studies, being conducted internally or through CROs.
  • Critically evaluate and interpret results of all safety pharmacology and toxicology studies to internal project teams and executive management.
  • Serve as the internal Subject Matter Expert for non-clinical safety pharmacology and toxicology for internal and external stakeholders.
  • Author, review and/or edit safety pharmacology and toxicology sections of regulatory documents to include INDs, CTAs, FDA Briefing Documents, Investigator Brochures, etc.
  • Participate in interactions and/or represent Janux Therapeutics with global regulatory authorities.
  • Develop optimal CRO network for toxicology studies, build and maintain effective vendor relationships.
  • Other duties as necessary.

Required Skills/Qualifications:

  • A Master’s Degree in Toxicology or a relevant field with 12+ years of experience as a toxicologist within the biotech/pharmaceutical industry is required. A PhD graduate with 8+ years of industry experience is highly preferred and will be given priority.
  • Board certification in Toxicology is highly desired.
  • Previous large molecule development experience and/or oncology product development experience within a biotech/pharmaceutical organization is preferred.
  • Strong familiarity with GLP regulations and regulatory guidelines for the testing of products and experience with compilation of toxicology data into regulatory submission documents is required.
  • Previous experience leading IND-enabling studies, and the creation of documents to support successful regulatory submissions is required.
  • Excellent written and verbal communication skills, ability to multi-task and shift priorities, and the ability to work well with cross functional teams is essential.
  • Enthusiastic, self-motivated, and keen to improve processes and overcome inefficiencies.


In addition to a competitive compensation package with stock options and stock purchase plan, Janux also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance is also available.

Job Type: Full-time


  • 401K
  • Medical insurance
  • Dental insurance
  • Vision insurance
  • Supplemental disability insurance plans
  • Flexible schedule
  • Life insurance
  • Flexible vacation
  • Sick time
  • Incentive stock option plan
  • Relocation assistance


  • Monday to Friday

Work authorization:

  • United States (Required)

Additional Compensation:

  • Annual targeted bonus %

Work Location:

  • On site – La Jolla/Torrey Pines
  • Remote

COVID-19 Vaccination required

Janux requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Janux will consider requests for Reasonable Accommodations.


Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity